Format

Send to

Choose Destination
Annu Rev Med. 1992;43:117-24.

Chronic granulomatous disease.

Author information

1
Division of Hematology/Oncology, Children's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts.

Abstract

Chronic granulomatous disease (CGD) encompasses a group of rare inherited disorders characterized by defects in a phagocyte-specific NADPH-oxidase complex that forms the superoxide radical during the respiratory burst. In this chapter, the protein components and cellular biochemistry of the oxidase are reviewed in light of recent genetic and biochemical studies of CGD. The classification and molecular genetic analysis of CGD is discussed. Finally, the use of recombinant human interferon-gamma as a new therapeutic agent for management of the disorder is reviewed.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center