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Nutr Rev. 1992 Feb;50(2):47-8.

A retrovirus uses a cationic amino acid transporter as a cell surface receptor.

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Department of Pediatrics, University of California at San Diego, La Jolla 92093.


New studies have indicated that the cell membrane receptor for the ecotropic murine leukemia virus is the classic membrane amino acid transporter y+, the principal transporter of cationic L-acids in mammalian cells. This finding has been hailed as a landmark in cell physiology which may reveal new mechanisms of viral pathogenesis. These studies represent the first amino acid transporter to be cloned, as well as the first example of a virus subverting a transmembrane protein as a receptor.

[Indexed for MEDLINE]

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