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FEBS Lett. 1992 Apr 20;301(2):231-5.

Ubiquitin, a central component of selective cytoplasmic proteolysis, is linked to proteins residing at the locus of non-selective proteolysis, the vacuole.

Author information

1
Institut für Biochemie, Universität Stuttgart, Germany.

Abstract

Ubiquitin, an evolutionary highly conserved protein, is known to be involved in selective proteolysis in the cytoplasm. Here we show that ubiquitin-protein conjugates are also found in the yeast vacuole. Mutants defective in the major vacuolar endopeptidases, proteinase yscA and yscB, lead to accumulation of ubiquitin-protein conjugates in this cellular organelle.

PMID:
1314742
DOI:
10.1016/0014-5793(92)81254-j
[Indexed for MEDLINE]
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