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Zhonghua Xin Xue Guan Bing Za Zhi. 1992 Oct;20(5):310-2, 325.

[A study of the antiarrhythmic mechanism of berberine on delayed activation potassium current by voltage clamp].

[Article in Chinese]

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Shanghai Xu Hui District Central Hospital.


The effects of berberine (0.1-10 mg/L) on delayed activation potassium current (iK) of canine Purkinje fibers were studied with two-microelectrode voltage clamp technique. Berberine (Ber) significantly reduced the amplitude of iK in concentration-dependent manner. When perfused with 10 mg/L Ber, the amplitude of tail current of the Purkinje fibers decreased immediately and the inhibition rate was 73.6 +/- 4.5% (n = 9, P < 0.001). The inhibition effect of berberine on iK may explain its prolongation effect on action potential duration and its antiarrhythmic action.

[Indexed for MEDLINE]

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