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Acta Physiol Hung. 1992;79(2):119-24.

Extension of lifespan in mice treated with Dinh lang (Policias fruticosum L.) and (-)deprenyl.

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Department of Pharmacology, Semmelweis University Medical School, Budapest, Hungary.


The effect of Dinh lang root extract (DLRE) and (-)deprenyl on memory function and lifespan was examined in OFA-1 male mice. Treatments of either DLRE, (-)deprenyl or their combination were carried out 3 times a week starting at 12 months of age and following to the end of life. DLRE and (-)deprenyl significantly increased the memory function as well as surviving time of aged mice. The drug-treated animals showed a lower rate of loss of body weight than saline treated ones. It suggested that DLRE and (-)deprenyl did not prolong lifespan of mice by suppressing food intake. The combined treatment of DLRE and (-)deprenyl proved to be the most effective.

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