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Nat Genet. 1992 Oct;2(2):128-31.

Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome.

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Department of Pathology, University of Cambridge, UK.


A predisposing gene for breast and ovarian cancer has recently been mapped to chromosome 17q12-21. If this gene is a tumour suppressor gene, allele losses would be expected in the tumours of affected family members and the losses should affect the wild-type chromosome, reflecting the need for inactivation of the wild-type allele at the predisposing locus. In four multiple case breast-ovarian cancer families, we have found that in each of nine tumours which showed allele losses, the losses were from the wild-type chromosome. This suggests that the putative 'breast-ovarian' cancer gene is indeed a tumour suppressor gene.

[Indexed for MEDLINE]

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