Localization of cannabinoid receptor in the human developing and adult basal ganglia. Higher levels in the striatonigral neurons

Neurosci Lett. 1992 Dec 14;148(1-2):173-6. doi: 10.1016/0304-3940(92)90832-r.

Abstract

In the infant and adult human basal ganglia, the finding of mRNA exclusively in the striatal medium-sized neurons together with the detection of [3H]CP55,940 binding sites in the caudate-putamen, accumbens, substantia nigra pars reticulata and globus pallidus suggests cannabinoid receptor localization on the striatal intrinsic enkephalinergic and substance P-projecting neurons and on their nigral and pallidal terminals. However, the consistent finding of higher binding in the substantia nigra pars reticulata and medial part of the globus pallidus over its lateral segment suggests cannabinoid receptor enrichment on the striatal substance P neurons which express selectively the dopamine D1 receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / metabolism*
  • Autoradiography
  • Basal Ganglia / growth & development
  • Basal Ganglia / metabolism*
  • Brain / growth & development
  • Brain / metabolism*
  • Cannabinoids / metabolism
  • Corpus Striatum / growth & development
  • Corpus Striatum / metabolism*
  • Cyclohexanols / metabolism
  • Humans
  • In Vitro Techniques
  • Infant
  • Infant, Newborn
  • Neurons / metabolism*
  • Neurons / physiology
  • Organ Specificity
  • RNA, Messenger / analysis
  • RNA, Messenger / metabolism
  • Receptors, Cannabinoid
  • Receptors, Drug / analysis
  • Receptors, Drug / genetics
  • Receptors, Drug / metabolism*
  • Substantia Nigra / growth & development
  • Substantia Nigra / metabolism*
  • Tritium

Substances

  • Cannabinoids
  • Cyclohexanols
  • RNA, Messenger
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Tritium
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol