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J Exp Med. 1952 Nov;96(5):491-7.

Adaptation of Group B Coxsackie virus to adult mouse pancreas.

Abstract

An alteration of tissue tropism of a Coxsackie virus has been observed following different methods of propagation of the virus in animals. Tropism for the adult mouse pancreas, as described by Pappenheimer, appeared to be irrevocably lost following prolonged brain-to-brain transfer. It was present in the same strain on reisolation from human feces, was intensified following pancreas transfers, and suppressed by brain transfers. Pancreatotropism may be correlated with the titer of virus in the pancreas.

PMID:
13000059
PMCID:
PMC2136156
DOI:
10.1084/jem.96.5.491
[Indexed for MEDLINE]
Free PMC Article

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