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Genes Dev. 2003 Oct 1;17(19):2362-7. Epub 2003 Sep 15.

An essential role of Bmp4 in the atrioventricular septation of the mouse heart.

Author information

1
Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

Abstract

Proper septation and valvulogenesis during cardiogenesis depend on interactions between the myocardium and the endocardium. By combining use of a hypomorphic Bone morphogenetic protein 4 (Bmp4) allele with conditional gene inactivation, we here identify Bmp4 as a signal from the myocardium directly mediating atrioventricular septation. Defects in this process cause one of the most common human congenital heart abnormalities, atrioventricular canal defect (AVCD). The spectrum of defects obtained through altering Bmp4 expression in the myocardium recapitulates the range of AVCDs diagnosed in patients, thus providing a useful genetic model with AVCD as the primary defect.

PMID:
12975322
PMCID:
PMC218073
DOI:
10.1101/gad.1124803
[Indexed for MEDLINE]
Free PMC Article

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