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Nat Rev Immunol. 2003 Aug;3(8):667-76.

Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators.

Author information

1
Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Université de Louvain, 74 Avenue Hippocrate, B1200 Brussels, Belgium. jean-christophe.renauld@bru.licr.org

Abstract

Class II cytokine receptors were originally defined on the basis of sequence homologies in the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and the ligands, known as class II cytokines, also have a common structure. More recently, a series of new receptors and cytokines that belong to this family have been discovered. The therapeutic potential of the 'old' members of this family, IFNs and IL-1, is recognized in the clinic, and the existence of structurally related molecules is raising expectations for additional clinical applications. In this review, I discuss both structural and biological data that are emerging about this family of receptors and ligands, to highlight the potential applications of modulating the activity of these cytokines.

PMID:
12974481
DOI:
10.1038/nri1153
[Indexed for MEDLINE]

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