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Nat Neurosci. 2003 Oct;6(10):1021-2. Epub 2003 Sep 14.

Osmometry in osmosensory neurons.

Author information

1
Centre for Research in Neuroscience, Montreal General Hospital & McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.

Abstract

Mechanosensitive channels may act as osmosensory transducers because osmotically evoked changes in cell volume alter forces applied to the channel and affect opening probability. However, osmotically stimulated cells regulate volume normally, whereas systemic osmoregulatory responses are sustained. Here we report that osmosensory neurons of rat supraoptic nucleus expressed significant membrane reserves, and could not regulate volume or total membrane surface area during osmotic perturbations, which may allow mechanosensitive channels to encode the amplitude and time course of an osmotic stimulus.

PMID:
12973356
DOI:
10.1038/nn1124
[Indexed for MEDLINE]

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