Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Pharm. 2003 Oct 2;264(1-2):45-55.

Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization.

Author information

1
Departamento de Farmácia e Farmacologia, Universidade Estadual de Maringá, Av. Colombo 5790, CEP 87020-900, Maringá, PR, Brazil.

Abstract

Gelatin microparticles containing propolis extractive solution (PES) were prepared by spray-drying technique. The optimization of the spray-drying operating conditions and the proportions of gelatin and mannitol were investigated. Regular particle morphology was obtained when mannitol was used, whereas mannitol absence produced a substantial number of coalesced and agglomerated microparticles. Microparticles had a mean diameter of 2.70 microm without mannitol and 2.50 microm with mannitol. The entrapment efficiency for propolis of the microparticles was upto 41% without mannitol and 39% with mannitol. The microencapsulation by spray-drying technique maintained the activity of propolis against Staphylococcus aureus. These gelatin microparticles containing propolis would be useful for developing intermediary or eventual propolis dosage form without the PES' strong and unpleasant taste, aromatic odour, and presence of ethanol.

PMID:
12972335
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center