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Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain.

Author information

1
Department of Biochemistry, Faculty of Science, Mahidol University, Phya Thai, Bangkok, Thailand. scrth@mahidol.ac.th

Abstract

The role of myosin phosphorylation by myosin light chain kinase (MLCK) in regulating the invasiveness of metastatic cancer cells was investigated using the Dunning rat prostatic adenocarcinoma cell line, Mat Ly Lu, and in vitro invasion assay. Treatment with MLCK inhibitors resulted in marked reduction of invasiveness, which was principally due to impaired cellular motility, whereas the ability to survive and proliferate, to adhere to matrix, and to secrete gelatinases were minimally affected.

PMID:
12970723
DOI:
10.1038/sj.pcan.4500663
[Indexed for MEDLINE]

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