Format

Send to

Choose Destination
Fertil Steril. 2003 Sep;80(3):643-5.

Monozygotic twins discordant for vaginal agenesis and bilateral tibial longitudinal deficiency.

Author information

1
Department of Obsterics and Gynacology, Division of Reproductive Endocrinology and Infertility, University of Alabama at Birmingham, Birmingham, Alabama 35249-7333, USA. msteinkampf@uabmc.edu

Abstract

OBJECTIVE:

To report the first case of monozygotic twins with discordant congenital anomalies.

DESIGN:

Descriptive case report.

SETTING:

University hospital.

PATIENT(S):

A 20-year woman with complete vaginal agenesis (Mayer-Rokitansky-Kuster-Hauser syndrome) and right renal agenesis presented for creation of a neovagina. She had a monozygous twin confirmed by DNA testing using short tandem repeat (STR) loci; the twin had normal mullerian/mesonephric development but isolated bilateral tibial longitudinal deficiency.

INTERVENTION(S):

The complete history, physical, and laboratory data of both the patient and her twin. Also, operative laparoscopy with creation of a neovagina in the patient.

MAIN OUTCOME MEASURE(S):

Diagnosis and appropriate treatment of Mayer-Rokitansky-Kuster-Hauser syndrome and DNA testing with STR loci for monozygosity.

RESULT(S):

The surgical resection of the bilateral uterine remnants, creation of a neovagina in the patient, and the demonstration of monozygosity with her twin with bilateral tibial longitudinal deficiency.

CONCLUSION(S):

This case report suggests a link between developmental abnormalities of the genital and skeletal system.

PMID:
12969715
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center