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Eur J Obstet Gynecol Reprod Biol. 2003 Oct 10;110(2):149-52.

Treatment of asymptomatic bacterial vaginosis to prevent pre-term delivery: a randomised trial.

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1
Clinica Ostetrico Ginecologica, Università di Trieste, Trieste, Italy.

Abstract

OBJECTIVES:

To evaluate the efficacy of clindamycin vaginal cream 2% once daily for 7 days in prolonging pregnancy.

STUDY DESIGN:

Randomised clinical trial of 112 women between 14 and 25 weeks of gestation with diagnosis of asymptomatic bacterial vaginosis were enrolled in a multicenter randomised trial and assigned to active or no treatment. A total of 55 women were assigned to clindamycin and 57 to no treatment.

MAIN OUTCOME MEASURE:

frequency of pre-term delivery.

RESULTS:

The rates of pre-term delivery was 12.2% in the clindamycin group and 15.7% in the no treatment group (P=0.78). Birth weight was <2500 g in three and seven babies, respectively, in the two groups (P=0.32). Mean gestational ages at birth were 38.9 and 39.2 (P=0.52), respectively, in the clindamycin and no treatment groups.

CONCLUSIONS:

The results of this study suggest that treating asymptomatic bacterial vaginosis does neither markedly prolong pregnancy nor increase birthweight.

PMID:
12969574
[Indexed for MEDLINE]
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