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Aliment Pharmacol Ther. 2003 Sep 15;18(6):615-25.

Helicobacter pylori eradication is beneficial in the treatment of functional dyspepsia.

Author information

1
Otto-von-Guericke-Universität, Zentrum für Innere Medizin, Magdeburg, Germany. peter.malfertheiner@medizin.uni-magdeburg.de

Abstract

AIM:

To assess whether the eradication of Helicobacter pylori leads to long-term relief of symptoms in functional dyspepsia.

METHODS:

Eight hundred patients with functional dyspepsia were randomized to receive double-blind treatment with twice-daily 30 mg lansoprazole, 1000 mg amoxicillin and 500 mg clarithromycin for 7 days (L30AC), twice-daily 15 mg lansoprazole, 1000 mg amoxicillin and 500 mg clarithromycin for 7 days (L15AC), or once-daily 15 mg lansoprazole for 14 days (LP). Dyspepsia and reflux symptoms were monitored for 12 months.

RESULTS:

In intention-to-treat analysis, the non-ulcer dyspepsia sum score showed a statistically significant benefit in terms of symptom relief in the L30AC group (P = 0.0068) compared with the LP group, but there was no significant difference between the L15AC and LP groups (P = 0.2). When all patients in the two eradication therapy arms were considered together, successful eradication had a significant benefit with regard to the complete absence of symptoms (P < 0.04). H. pylori eradication did not lead to an increase in reflux symptoms.

CONCLUSION:

This study suggests that H. pylori infection causes dyspeptic symptoms in a subset of patients with functional dyspepsia, and that these patients may obtain long-term symptomatic benefit following H. pylori eradication.

PMID:
12969088
[Indexed for MEDLINE]
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