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P N G Med J. 2002 Sep-Dec;45(3-4):219-21.

Paranoid psychosis related to mefloquine antimalarial prophylaxis.

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  • 1Sydney University Department of Medicine, Nepean Hospital, Australia.


Mefloquine is an important antimalarial drug for treatment and prophylaxis of chloroquine-resistant malaria. Its use has been associated with neuropsychiatric side-effects. We report a case of paranoid psychosis associated with mefloquine occurring in a remote part of Papua New Guinea. Adverse reactions and contraindications are discussed. This case underlines the importance of awareness of neuropsychiatric side-effects with mefloquine use and of taking a careful psychiatric history before prescribing mefloquine.

[PubMed - indexed for MEDLINE]
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