Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cardiothorac Vasc Anesth. 2003 Aug;17(4):491-4.

Fenoldopam for renal protection in patients undergoing cardiopulmonary bypass.

Author information

1
Department of Cardiac Surgery, University of East Piedmont, School of Medicine, Novara, Italy. philippeprimo.caimmi@tin.it

Abstract

OBJECTIVE:

To evaluate the possible protective effects of fenoldopam on renal function in patients undergoing cardiopulmonary bypass.

DESIGN:

Prospective, randomized trial.

SETTING:

University teaching hospital.

PARTICIPANTS:

One hundred sixty consecutive patients with serum creatinine >1.5 mg/dL who underwent uncomplicated moderate hypothermic cardiopulmonary bypass for cardiac surgery.

INTERVENTIONS:

A random group of 80 patients was managed conventionally (group A), whereas another random group of 80 patients received continuous intravenous administration of low-dose fenoldopam (0.1-0.3 microg/kg/min) during cardiopulmonary bypass and in the early postoperative period (group B).

MEASUREMENTS AND MAIN RESULTS:

An improvement of postoperative renal parameters were observed only in group B: preoperative serum creatinine 1.82 +/- 0.2 versus 1.43 +/- 0.73 postoperatively (p < 0.001), preoperative creatinine clearance 51.34 +/- 22.26 versus 67.14 +/- 18.55 postoperatively (p < 0.001).

CONCLUSIONS:

In this study, fenoldopam was an effective agent in the prevention of renal dysfunction after cardiopulmonary bypass.

PMID:
12968238
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center