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Trends Pharmacol Sci. 2003 Sep;24(9):486-92.

Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.

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Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA.


Abnormal activity of the dopamine system has been implicated in several psychiatric and neurological illnesses; however, lack of knowledge about the precise sites of dopamine dysfunction has compromised our ability to improve the efficacy and safety of dopamine-related drugs used in treatment modalities. Recent work suggests that dopamine transmission is regulated via the concerted efforts of a cohort of cytoskeletal, adaptor and signaling proteins called dopamine receptor-interacting proteins (DRIPs). The discovery that two DRIPs, calcyon and neuronal Ca(2+) sensor 1 (NCS-1), are upregulated in schizophrenia highlights the possibility that altered protein interactions and defects in Ca(2+) homeostasis might contribute to abnormalities in the brain dopamine system in neuropsychiatric diseases.

[Indexed for MEDLINE]

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