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DNA Repair (Amst). 2003 Sep 18;2(9):955-69.

XRCC1 and DNA strand break repair.

Author information

1
Genome Damage and Stability Centre, University of Sussex, Science Park Road, BN1 9RQ, Falmer Brighton, UK. k.w.caldecott@sussex.ac.uk

Abstract

DNA single-strand breaks can arise indirectly, as normal intermediates of DNA base excision repair, or directly from damage to deoxyribose. Because single-strand breaks are induced by endogenous reactive molecules such as reactive oxygen species, these lesions pose a continuous threat to genetic integrity. XRCC1 protein plays a major role in facilitating the repair of single-strand breaks in mammalian cells, via an ability to interact with multiple enzymatic components of repair reactions. Here, the protein-protein interactions facilitated by XRCC1, and the repair processes in which these interactions operate, are reviewed. Models for the repair of single-strand breaks during base excision repair and at direct breaks are presented.

PMID:
12967653
DOI:
10.1016/s1568-7864(03)00118-6
[Indexed for MEDLINE]

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