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Arch Pharm Res. 2003 Aug;26(8):597-600.

Gram-positive bacteria specific properties of silybin derived from Silybum marianum.

Author information

1
Research Center for Proteineous Materials, Chosun University, Korea.

Abstract

Silybin has a potent antibacterial activity, more potent than silymarin II, against gram-positive bacteria without hemolytic activity, whereas it has no antimicrobial activity against gram-negative bacteria or fungi. The mode of action of silybin against the gram-positive bacterial cell was examined by investigating the change in plasma membrane dynamics of bacterial cells using 1,6-diphenyl-1,3,5-hextriene (DPH) as a membrane probe and by assessing the inhibition of macromolecular synthesis using radiolabeled incorporation assay. The results showed that silybin inhibited RNA and protein synthesis on gram-positive bacteria.

PMID:
12967193
DOI:
10.1007/bf02976707
[Indexed for MEDLINE]

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