Send to

Choose Destination
See comment in PubMed Commons below
WMJ. 2003;102(4):43-5.

Myeloneuropathy from nitrous oxide abuse: unusually high methylmalonic acid and homocysteine levels.

Author information

  • 1Department of Neurology, University of Wisconsin Medical School, Madison, Wis. 53792, USA.

Erratum in

  • WMJ. 2003;102(6):5.


A 23-year-old patient developed diffuse paresthesias and sensory loss. He had mildly reduced serum vitamin B12 (B12) concentration with unusually high levels of methylmalonic acid (MMA) and homocysteine and no evidence of B12 malabsorption. Following parenteral B12 administration, his neurological deficit promptly resolved and B12 and MMA levels normalized, but elevated levels of homocysteine persisted. One year later, he admitted to inhaling nitrous oxide (N2O). After halting N2O abuse his homocysteine level normalized. This case demonstrates the importance of serum homocysteine level measurements in cases of suspected N2O toxicity [corrected].

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wisconsin Medical Journal
    Loading ...
    Support Center