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Clin Diagn Lab Immunol. 2003 Sep;10(5):741-3.

High levels of interleukin-1 in patients with endemic pemphigus foliaceus.

Author information

1
Faculdade de Medicina do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.

Abstract

Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response.

PMID:
12965897
PMCID:
PMC193914
DOI:
10.1128/cdli.10.5.741-743.2003
[Indexed for MEDLINE]
Free PMC Article

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