Format

Send to

Choose Destination
J Infect Dis. 2003 Sep 15;188(6):919-26. Epub 2003 Aug 26.

Correlation between mortality and the levels of inter-alpha inhibitors in the plasma of patients with severe sepsis.

Author information

1
Brown Medical School, Division of Medical Oncology/Department of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA. Yow-Pin_Lim_MD@Brown.edu

Abstract

Inter-alpha inhibitor protein (IalphaIp) is an endogenous serine protease inhibitor in human plasma. Circulating IalphaIp levels were lower in 51 patients with severe sepsis than in healthy volunteers. Mean levels were 688+/-295 mg/L in patients with severe sepsis who survived (n=32), 486+/-193 mg/L in patients with sepsis who died (n=19), and 872+/-234 mg/L in control subjects (n=25). IalphaIp levels were lower in patients with shock versus those without (540+/-246 [n=33] vs. 746+/-290 [n=18] mg/L; P=.0102). IalphaIp levels were inversely correlated with 28-day mortality rates and Acute Physiology and Chronic Health Evaluation II scores and directly correlated with antithrombin III, protein C, and protein S levels. The administration of IalphaIp (30 mg/kg body weight intravenously) increased the 50% lethal dose in mice by 100-fold after an intravenous challenge of Escherichia coli. Thus, human IalphaIp may be a useful predictive marker and potential therapeutic agent in sepsis.

PMID:
12964125
DOI:
10.1086/377642
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center