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J Am Acad Dermatol. 2003 Sep;49(3):433-9.

DNA repair and nonmelanoma skin cancer in Puerto Rican populations.

Author information

1
Department of Pharmacology and Toxicology, Ponce School of Medicine, Puerto Rico 00732, USA.

Abstract

BACKGROUND:

UV radiation is a risk factor for nonmelanoma skin cancer (NMSC). The relation between DNA damage and oncogenesis suggests that diminished DNA repair capacity (DRC) is involved in tumorigenesis.

OBJECTIVE:

The purpose of this study was to test the hypothesis that a low DRC is a susceptibility factor for the development of NMSC in Puerto Rico.

METHODS:

A case-control retrospective clinical study was done to compare the age-adjusted DRC in participants with and without NMSC. DRC was measured using a host cell reactivation assay with a luciferase reporter gene irradiated with UV light and transfected into human peripheral lymphocytes. An epidemiologic questionnaire was used to solicit risk factors.

RESULTS:

The mean (+/-2 SE) DRC of 177 control patients without skin cancer was 8.6% +/- 0.7. Participants (280) with NMSC had a 42% lower DRC (5.0% +/- 0.3).

CONCLUSION:

A low DRC is a susceptibility factor for NMSC.

PMID:
12963906
[Indexed for MEDLINE]

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