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Biochem Biophys Res Commun. 2003 Sep 26;309(3):495-501.

Recent advances in computational promoter analysis in understanding the transcriptional regulatory network.

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Bioinformatics Group and Discovery Technology Department at Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.


The computational approach to the study of transcriptional regulation networks has become more attractive and feasible with the rapid accumulation of complete genome sequences and the advance of high-throughput expression profiling technology. In this review, current computational approaches for understanding the transcriptional regulatory network, including promoter prediction, transcription factor binding site identification, combinatorial regulatory elements prediction, and transcription factor target gene identification, are discussed. The role of comparative genomics in transcription regulatory region analysis is also reviewed.

[Indexed for MEDLINE]

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