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Appl Opt. 2003 Sep 1;42(25):5181-90.

Tomographic optical breast imaging guided by three-dimensional mammography.

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  • 1Department of Physics, Tufts University, Medford, Massachusetts 02155, USA.


We introduce a modified Tikhonov regularization method to include three-dimensional x-ray mammography as a prior in the diffuse optical tomography reconstruction. With simulations we show that the optical image reconstruction resolution and contrast are improved by implementing this x-ray-guided spatial constraint. We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method.

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