CD4+ T cell matters in tumor immunity

Int Rev Immunol. 2003 Mar-Apr;22(2):113-40. doi: 10.1080/08830180305220.

Abstract

CD4+ T cells have been shown to be able to affect tumor growth through both direct and indirect means. In addition, a requirement has been demonstrated for CD4+ T cells in the regulation and induction of T cell memory, and CD4+ suppressor T cells have been identified, stressing a role for CD4+ T cells in the induction and maintenance of antitumor immune responses. A review of the involvement of CD4+ T cells at different stages of tumor immunity is provided, and based on these data we discuss how CD4+ T cell response induction could be incorporated into tumor immunotherapy strategies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antibodies, Neoplasm / immunology
  • B-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • Cancer Vaccines / immunology
  • Humans
  • Interferon-gamma / physiology
  • Neoplasms / immunology*
  • Neovascularization, Pathologic / immunology

Substances

  • Antibodies, Neoplasm
  • Cancer Vaccines
  • Interferon-gamma