The present article reviews the historic background of research in the Spanish University and particularly biomedical research in our country. We analyze the last set of data facilitated by the University Council and the Consejo Superior de Investigaciones Científicas. We also review the implications that the National Plan of Quality has had on university research, clearly stimulating and improving the system, and new transformations that the Organic Law of Universities brings implied, and more specifically the National System of Qualification for the access to university teaching staff, which has research work of the teachers as the essential key. Finally, we review the biomedical scientific production during the last years by topics and universities, reflecting the improvement seen during the last decade not only in quantity but also in quality, which is more important. In conclusion, the review reflects a notable change in biomedical research in our universities opening an encouraging track for the future of research.