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Curr Biol. 2003 Sep 2;13(17):R678-80.

Epithelial migration: open your eyes to c-Jun.

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Viral Carcinogenesis Laboratory, Cancer Research UK London Research Institute, 61 Lincoln's Inn Fields, WC2A 3PX, London, UK.


Tissue-specific removal of c-jun from epidermal cells in mice leads to a failure of eyelid fusion during embryogenesis and reveals roles for c-Jun in wound repair and tumorigenesis in adult skin. This has provided a definitive test of the in vivo function of AP-1 signalling and shown that EGF signalling is key to all of c-Jun's roles in the epidermis.

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