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Int J Clin Oncol. 2003 Aug;8(4):187-92.

Translational and clinical studies of target-based cancer therapy.

Author information

1
National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Abstract

The increasing number of negative trials in cancer treatment has prompted a systematic re-evaluation of target-based drugs. It is our impression that the sensitivity of current clinical trial methodology is inadequate to demonstrate the effectiveness of target-based drugs, in terms of tumor shrinkage, delay in progression, or improved survival. Enrichment of sensitive populations, based on the data from translational studies, is essential for a better understanding of the role of novel therapies in cancer. Translational and clinical studies are key to the identification and maximization of benefit of target-based therapy.

PMID:
12955572
DOI:
10.1007/s10147-003-0324-x
[Indexed for MEDLINE]

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