Format

Send to

Choose Destination
Springer Semin Immunopathol. 2003 Sep;25(2):167-80.

Immunopathology of human T cell responses to skin, artery and endothelial cell grafts in the human peripheral blood lymphocyte/severe combined immunodeficient mouse.

Author information

1
Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue-Room 454, New Haven, CT 06510, USA.

Abstract

Blood vessels and their endothelial lining are major stimulators and targets of the rejection response. The immunological properties of human endothelial cells differ significantly from those of other species and new models are needed for proper study of human vessels in the transplant setting. We have employed the human peripheral blood lymphocyte/severe combined immunodeficiency (huPBL/SCID) mouse for this purpose. We describe here our results involving transplantation of human skin, human artery and cultured human endothelial cells. We also describe our more limited experience using porcine skin and artery transplantation to study human T cells responses to pig endothelium.

PMID:
12955465
DOI:
10.1007/s00281-003-0135-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center