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Biochem J. 2003 Sep 15;374(Pt 3):e1-2.

Trials, tribulations and finally, a transporter: the identification of the mitochondrial pyruvate transporter.

Author information

1
Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Sciences, Barts and the London, Queen Mary's School of Medicine and Dentistry, University of London, London, UK. m.c.sugden@qmul.ac.uk

Abstract

Pyruvate occupies a central role in energy homoeostasis, and dysregulation of its cellular disposition underlies many metabolic disturbances. Although the mitochondrial membrane pyruvate transporter has been characterized, its molecular identity has proved elusive. Recent work has now identified a single candidate protein for the mitochondrial pyruvate carrier in yeast, opening the way for further studies in mammalian systems, which may have important therapeutic applications within the context of metabolic disease.

PMID:
12954079
PMCID:
PMC1223652
DOI:
10.1042/bj20031105
[Indexed for MEDLINE]
Free PMC Article

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