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J Med Chem. 2003 Sep 11;46(19):3957-60.

The first potent and selective non-imidazole human histamine H4 receptor antagonists.

Author information

1
Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield Row, San Diego, California 92121, USA.

Abstract

Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.

PMID:
12954048
DOI:
10.1021/jm0341047
[Indexed for MEDLINE]

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