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Nat Rev Cancer. 2003 Sep;3(9):666-75.

Adoptive-cell-transfer therapy for the treatment of patients with cancer.

Author information

1
Surgery Branch, National Cancer Institute, Building 10, Room 2B-34, 10 Center Drive, Bethesda, Maryland 20892-1502, USA. Mark_Dudley@nih.gov

Abstract

Adoptive immunotherapy--the isolation of antigen-specific cells, their ex vivo expansion and activation, and subsequent autologous administration--is a promising approach to inducing antitumour immune responses. The molecular identification of tumour antigens and the ability to monitor the persistence and transport of transferred cells has provided new insights into the mechanisms of tumour immunotherapy. Recent studies have shown the effectiveness of cell-transfer therapies for the treatment of patients with selected metastatic cancers. These studies provide a blueprint for the wider application of adoptive-cell-transfer therapy, and emphasize the requirement for in vivo persistence of the cells for therapeutic efficacy.

PMID:
12951585
PMCID:
PMC2305722
DOI:
10.1038/nrc1167
[Indexed for MEDLINE]
Free PMC Article
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