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Nat Rev Cancer. 2003 Sep;3(9):639-49.

Origins of chromosome translocations in childhood leukaemia.

Author information

1
LRF Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK. mel.greaves@icr.ac.uk

Abstract

Chromosome translocations are often early or initiating events in leukaemogenesis, occurring prenatally in most cases of childhood leukaemia. Although these genetic changes are necessary, they are usually not sufficient to cause leukaemia. How, when and where do translocations arise? And can these insights aid our understanding of the natural history, pathogenesis and causes of leukaemia?

PMID:
12951583
DOI:
10.1038/nrc1164
[Indexed for MEDLINE]

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