Format

Send to

Choose Destination
Clin Biochem. 2003 Sep;36(6):471-81.

Tandem mass spectrometry in the clinical chemistry laboratory.

Author information

1
Department of Pathology and Laboratory Medicine, IWK Health Centre and Department of Pathology, Dalhousie University Medical School, Halifax, Nova Scotia, Canada. kent.dooley@iwk.nshealth.ca

Abstract

Tandem mass spectrometry is becoming an increasingly important analytical technology in the clinical laboratory environment. Applications in toxicology and therapeutic drug monitoring have opened the door for tandem mass spectrometry and now we are seeing a vast array of new applications being developed. It has been the combination of tandem mass spectrometry with sample introduction techniques employing atmospheric pressure ionization that has enabled this technology to be readily implemented in the clinical laboratory. Although its major research applications started with pharmacology and proteomics, tandem mass spectrometry is being used for a great variety of analyses from steroids to catecholamines to peptides. As with chromatographic methods, tandem mass spectrometry is most cost effective when groups of compounds need to be measured simultaneously. However as the price/performance of this technology continues to improve, it will become even more widely utilized for clinical laboratory applications.

PMID:
12951172
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center