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Bioorg Med Chem Lett. 2003 Oct 6;13(19):3129-32.

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.

Author information

1
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. zhonghua.pei@abbott.com

Abstract

A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP.

PMID:
12951078
DOI:
10.1016/s0960-894x(03)00725-x
[Indexed for MEDLINE]

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