Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Immunol. 2003 Oct;4(10):974-81. Epub 2003 Aug 31.

Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.

Author information

  • 1Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA. ottv@njc.org

Abstract

Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation.

Comment in

PMID:
12949532
DOI:
10.1038/ni971
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center