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Nat Rev Immunol. 2003 Sep;3(9):757-64.

Reassessing the function of immune-complex retention by follicular dendritic cells.

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1
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA. ann.haberman@yale.edu

Abstract

The close association of follicular dendritic cells (FDCs) and germinal-centre B cells has fostered the idea that B-cell recognition of retained antigen that is presented on the surface of FDCs is important for affinity maturation and memory B-cell development. We argue that the retention of immune complexes is not required for germinal-centre development, affinity maturation and memory B-cell maintenance. Instead, it is probable that FDCs support B-cell proliferation and differentiation in a non-specific manner. Other potential roles of immune complexes retained by FDCs are discussed.

PMID:
12949499
DOI:
10.1038/nri1178
[Indexed for MEDLINE]
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