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Nat Rev Immunol. 2003 Sep;3(9):721-32.

The regulation of immunoglobulin E class-switch recombination.

Author information

1
Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA. raif.geha@tch.harvard.edu

Abstract

Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely allergic rhinitis, asthma and atopic dermatitis, but are also involved in host immune defence mechanisms against parasitic infection. The commitment of a B cell to isotype class switch to an IgE-producing cell is a tightly regulated process, and our understanding of the regulation of IgE-antibody production is central to the prevention and treatment of atopic disease. Both those that are presently in use and potential future therapies to prevent IgE-mediated disease take advantage of our existing knowledge of the specific mechanisms that are required for IgE class switching.

PMID:
12949496
DOI:
10.1038/nri1181
[Indexed for MEDLINE]

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