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Pediatrics. 2003 Sep;112(3 Pt 1):565-9.

Adverse effects of smoking on respiratory function in young adults born weighing less than 1000 grams.

Author information

1
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia. lwd@unimelb.edu.au

Abstract

OBJECTIVE:

To determine whether active smoking has an adverse impact on respiratory function of young adults of extremely low birth weight (ELBW; birth weight <1000 g).

METHODS:

This was a cohort study of 60 consecutive ELBW survivors who were born during 1977-1980 at Royal Women's Hospital, Melbourne, Australia. Respiratory function was measured on 44 (73%) of the subjects at a mean age of 20.2 years (standard deviation: 1.0 year). Respiratory function had also been measured on 42 of the 44 subjects at 8 years of age. Respiratory function was compared between the 14 smokers and the 30 nonsmokers.

RESULTS:

Several respiratory function variables reflecting airflow (the forced expired volume in 1 second [FEV(1)]/forced vital capacity [FVC] ratio; flow rates at 75%, 50%, and 25% of vital capacity; and mid-expiratory flow from 25% to 75% of vital capacity) were significantly diminished in smokers. The proportion with a clinically important reduction in the FEV(1)/FVC ratio (<75%) was significantly higher in smokers (64%) than in nonsmokers (20%). There was a significantly larger decrease in the FEV(1)/FVC ratio between ages 8 and 20 years in the smokers (mean change: -8.2%; 95% confidence interval: -14.1% to -2.4%)

CONCLUSIONS:

Active smoking by young adult survivors of ELBW is associated with reduced respiratory function.

PMID:
12949285
[Indexed for MEDLINE]
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