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Rheumatology (Oxford). 2004 Jan;43(1):95-9. Epub 2003 Aug 29.

Cardiovascular autonomic dysfunction in primary Sjögren's syndrome.

Author information

1
Department of Rheumatology, Faculty of Medicine, University of Szeged, Szeged, Hungary. kovl@in1st.szote.u-szeged.hu

Abstract

OBJECTIVE:

To assess the occurrence and clinical significance of a cardiovascular autonomic nervous system dysfunction in primary Sjögren's syndrome (pSS).

METHODS:

Fifty-one pSS patients participated in this case-control study. Heart rate and blood pressure variability measurements, spontaneous baroreflex sensitivity examinations and cardiovascular reflex tests were performed.

RESULTS:

The results of the heart rate and blood pressure variability measurements and also the baroreflex sensitivity parameters of the pSS patients peaked in the lowest percentile ranges of a database on 559 healthy control subjects (P < 0.05). In three of the five cardiovascular reflex tests, the frequencies of abnormal results were significantly higher among the patients than among the controls (P < 0.05), and the median autonomic neuropathy score was also elevated (3 vs 0 in the controls; P < 0.0001).

CONCLUSION:

Signs of an autonomic nervous system dysfunction involving the cardiovascular system can be discerned in the majority of pSS patients.

PMID:
12949253
DOI:
10.1093/rheumatology/keg468
[Indexed for MEDLINE]

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