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Curr Opin Struct Biol. 2003 Aug;13(4):418-23.

Formate dehydrogenase--a versatile enzyme in changing environments.

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Division of Biomedical Sciences Imperial College London, London SW7 2AZ, UK.


Several structures belonging to the large bis-molybdopterin guanine dinucleotide enzyme family have been published during the past four years. These include the structures of three formate dehydrogenases containing intrinsic selenocysteine residues - two soluble enzymes and one integral membrane protein. Together these have given detailed structural and mechanistic information about this family of enzymes.

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