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Neuroimage. 2003 Aug;19(4):1303-16.

Region of interest based analysis of functional imaging data.

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Department of Cognitive and Neural Systems, Boston University, 677 Beacon Street, Boston, MA 02215, USA.


fMRI analysis techniques are presented that test functional hypotheses at the region of interest (ROI) level. An SPM-compatible Matlab toolbox has been developed that allows the creation of subject-specific ROI masks based on anatomical markers and the testing of functional hypotheses on the regional response using multivariate time-series analysis techniques. The combined application of subject-specific ROI definition and region-level functional analysis is shown to appropriately compensate for intersubject anatomical variability, offering finer localization and increased sensitivity to task-related effects than standard techniques based on whole-brain normalization and voxel or cluster-level functional analysis, while providing a more direct link between discrete brain region hypotheses and the statistical analyses used to test them.

[Indexed for MEDLINE]

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