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Neuroimage. 2003 Aug;19(4):1303-16.

Region of interest based analysis of functional imaging data.

Author information

1
Department of Cognitive and Neural Systems, Boston University, 677 Beacon Street, Boston, MA 02215, USA. alfnie@bu.edu

Abstract

fMRI analysis techniques are presented that test functional hypotheses at the region of interest (ROI) level. An SPM-compatible Matlab toolbox has been developed that allows the creation of subject-specific ROI masks based on anatomical markers and the testing of functional hypotheses on the regional response using multivariate time-series analysis techniques. The combined application of subject-specific ROI definition and region-level functional analysis is shown to appropriately compensate for intersubject anatomical variability, offering finer localization and increased sensitivity to task-related effects than standard techniques based on whole-brain normalization and voxel or cluster-level functional analysis, while providing a more direct link between discrete brain region hypotheses and the statistical analyses used to test them.

PMID:
12948689
[Indexed for MEDLINE]

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