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Trends Neurosci. 2003 Sep;26(9):453-5.

Dishevelled: linking convergent extension with neural tube closure.

Author information

1
Neural Development Unit, Institute of Child Health, University College, London WC1N 1EH, UK. a.copp@ich.ucl.ac.uk

Abstract

Neural tube closure fails in both mouse and Xenopus when dishevelled and other components of the planar-cell-polarity pathway are misregulated. The underlying defect involves a failure of convergent extension in the midline of the early neural plate. Although bilateral neural folds form, they are abnormally far apart and cannot achieve the apposition necessary for neural tube closure.

PMID:
12948650
DOI:
10.1016/S0166-2236(03)00212-1
[Indexed for MEDLINE]

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