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Neuron. 2003 Aug 28;39(5):729-30.

A tale of timing and transport.

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Molecular Cellular and Integrative Physiology IDP Graduate Program, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.


Excitatory and inhibitory synapses show long-term plasticity, but spike timing-dependent plasticity was seen only at excitatory connections. No longer. In this issue of Neuron, Woodin et al. demonstrate that coincident pre- and postsynaptic activity acts on the neuronal K+/Cl- cotransporter KCC2 to shift the reversal potential for Cl- and thus alters the effectiveness of GABAergic synapses.

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