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Acta Paediatr. 2003 Aug;92(8):910-5.

Early chemotherapy for non-tuberculous mycobacterial infections in patients with cystic fibrosis.

Author information

1
Division of Respiratory Medicine and Allergology, Department of Medicine, Stockholm CF Centre , Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden. ulrica.forslow@hs.se

Abstract

AIM:

To evaluate the response rate to antimycobacterial drug therapy in patients with cystic fibrosis (CF) suffering from infection by non-tuberculous mycobacteria (NTM).

METHODS:

Ten patients, aged 10-34 y, out of 180 CF patients, were diagnosed with NTM disease. They had been regularly checked and examined for pulmonary symptoms, and had had chest X-rays and sputum cultures (including for mycobacteria) performed. One additional 36-y-old female received her CF diagnosis soon after the NTM diagnosis.

RESULTS:

Mycobacterium avium-intracellulare complex (MAC) was found in 10 out of 11 patients and M. kansasii in 1 patient. Treatment with antimycobacterial drugs resulted in clinical improvement (weight gain or stabilization of weight and/or improved or stabilized lung function in 8 out of 11 patients) and mycobacterial culture turned negative in 10 out of 1.

CONCLUSION:

Promising results may be associated with early intervention with antimycobacterial therapy in CF patients.

PMID:
12948065
DOI:
10.1080/08035250310004388
[Indexed for MEDLINE]

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