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Curr Opin Biotechnol. 2003 Aug;14(4):444-50.

The enzyme as drug: application of enzymes as pharmaceuticals.

Author information

1
Department of Cellular Genetics, BioMarin Pharmaceutical Inc., 46 Galli Drive, Novato, CA 94949, USA. mvellard@bmrn.com

Abstract

Enzymes as drugs have two important features that distinguish them from all other types of drugs. First, enzymes often bind and act on their targets with great affinity and specificity. Second, enzymes are catalytic and convert multiple target molecules to the desired products. These two features make enzymes specific and potent drugs that can accomplish therapeutic biochemistry in the body that small molecules cannot. These characteristics have resulted in the development of many enzyme drugs for a wide range of disorders.

PMID:
12943856
[Indexed for MEDLINE]

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