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Org Lett. 2003 Sep 4;5(18):3285-8.

Homeopathic ligand-free palladium as a catalyst in the heck reaction. A comparison with a palladacycle.

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1
DSM Pharma Chemicals-Advanced Synthesis, Catalysis & Development, P.O. Box 18, 6160 MD Geleen, The Netherlands.

Abstract

[reaction: see text] Ligand-free Pd(OAc)(2) can be used as a catalyst in the Heck reaction of aryl bromides as long as the amount of catalyst is kept between 0.01 and 0.1 mol %. At higher concentrations palladium black forms and the reaction stops. The actual catalyst is monomeric. Palladacycles merely serve as a source of ligand-free palladium in Heck reactions of aryl bromides.

PMID:
12943408
DOI:
10.1021/ol035184b
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